The Zero Exosome Shot is medicube's viral "spicule" serum — a needle-shaped, microneedling-inspired formula sold in three strengths (2,000 / 7,500 / 25,000 PPM) that's built to physically deliver exosomes and actives into the skin. What comes up in nearly every review before anything else is the sensation: this is a serum people can genuinely feel working, for better or worse.
What reviewers consistently praised
Several reviewers reported visibly brighter, smoother-looking skin within days of starting, with one comparing the results favorably to professional microneedling treatments they'd had done in-office. The three-step routine (Exosome Shot, followed by a serum, then a moisturizer) was repeatedly described as simple enough to stick with, and reviewers who paired it with medicube's companion products noted the pore and texture improvements felt more noticeable than using the shot alone.
What reviewers consistently pushed back on
The tingling is real, and reviewers are consistent about that — it's described as ranging from a mild prickling to a noticeable stinging sensation, particularly on thinner or more reactive areas of the face, and particularly at the stronger PPM levels. More than one reviewer specifically warned against pairing it with retinol or other strong actives in the same routine, and recommended patch-testing and starting with the mildest strength if you're new to the category. A couple of reviews also noted the bottle is on the small side for the price.
What reviewers liked
- Visibly brighter, smoother skin reported within days for several reviewers
- Simple three-step routine that's easy to stick with
- Stronger results when paired with medicube's companion serum and cream
- Three PPM strengths let you match intensity to skin tolerance
What reviewers flagged
- Tingling/prickling sensation is consistently reported, sometimes described as stinging
- Not recommended alongside retinol or other strong actives
- Small bottle size relative to price, per a few reviewers
- Requires patch-testing — not universally comfortable for reactive skin
Who this seems to fit
Based on the pattern across reviews, this fits people chasing visible pore and texture improvements who don't mind an active, noticeable sensation as part of the process — ideally starting at the mildest 2,000 PPM strength. Reviewers are fairly consistent that this isn't the pick for anyone with a compromised skin barrier, an active flare-up, or skin that reacts easily to mild acids and fragranced actives.
Is it worth the price?
Amazon prices shift regularly, so check the live price on the button below rather than relying on a fixed number here. Reviewers generally felt the results justified the cost for the 7,500 PPM version specifically, though a couple flagged the fluid volume as small for what you're paying.
Our take, based on the roundup
The consistent thread across reviews is that this genuinely feels like an active treatment rather than a soothing serum — the tingling isn't just marketing language, and reviewers who liked it liked it because of that intensity, not despite it. If you're new to spicule/microneedling-style skincare, starting mild and patch-testing first is the advice that comes up again and again.
Sources referenced for this roundup
- TODAY.com — hands-on review comparing results to professional microneedling
- EmpowerHerFame — detailed sensory experience and sensitivity guidance
- Beauty Bloom — pros/cons summary and usage tips
- medicube's published consumer test data — brand-sourced clinical/self-test figures